Therapeutic composition



been found that the-composition of the, present inventiondoes not have the property of than bacterici'des poses above state of treatment of lam-am.

Patented Oct. 2, 1928 UNITED v: 1m1'|:s PATENT oFFrcE- Q :r. mom, or Bose-nose,- (LOUIQIAII'A.

This invention is an improved composition of matter, of the cutie value, adapted to be applied as a bactericide to viable organisms as a remedy for and preventive of general application in cases where such. compositions are usuall employed, for instance, 1n connection with acerations,bruises, burns and similar types of wounds, skin diseases and the like,-.and is also particularlyadapted for use as a dentifrice in the form of mouth washes, tooth-paste and, in the medical treat m'ent -of pyorrhea alveolaris, gingivitis and vincentsangina. Q f

Most bactericides, J 'now in general use,

which are applicable in the above stated uses, 7

contain an agent whichatta'cks living tissue, when used in quantitiesor strengthsufiicient to be efiective, thereby causing'what is commonly termed as burns at the wound and having other disadvantageous efiects while seeking to remedy the. condition. It has destroying the living tissue above referred to, while at the same time is more efficacious (generally used for the purfor instance, in the case yorrhea, where there is gran'u ationof the gingivae and flowing pus dental membrane and the reconof the peri U struction of the alveolar process has been obtained after three treatments, thus indicating a high degree of utility forthe composition of this invention with attendingunex ected results;

e compound of this invention may be used in liquid form or may be mixed with a suitable carrier for the purpose of-a salve or balm, or as a tooth-paste with'one of several suitable bases. When medically treating pyorrhea alve'olaris, narrow strips of absorbent material have been saturated with the,liquid form of the compound and placed against the s.

Various other a vantages and characteristics of the-invention will ap car more clearly from a statement of the asic composition which comprises broadly, a salicylate, a halide andan organic mercury derivative of dibromfluor'escein in a suitable solvent vehicle, for such latter grain alcohol is preferably employed, although other solvent nurrceomosmon. g 4 mean w my a, 1931. s mnmaoamf vehicles could emplo' d, such as. other alcohols, glycerine, carriers. v

However, the following gives one example of a specific formula, which has given very. satisfacto results, although it should be understoo an other fluids as specified by way of example, to wit:

'1 sound of salicylic acid 5 uid ounces tincture of iodine v v 5 fluid ounces twope'r-cent-- solution of mercurochrome (disodium salt of dibromhydroxymercuifluorescein).

These elements are mixed-together by stirring or agitation in approxlmately seven that the invention is not re-/ strlcted to precise Lproportions or elements pints of alcohol, or other suitable vehicle or I carrier; and while definite proportions are above set forth, the same-may beyaried within wide limits without detriment to the eflicaciousness of the composition.

materi 1 1, if not entirely, in the intense stinging or smarting sensation when applied to delicate tissue, in contradistinction to alcohol, mercurochrome,-or" iodine in their The resent composition'is found to lack ordinary state and leaves no objectionable stain on the parts to which it is applied.

This, couple'd with the advantages aboveset forth. of not destroying living tissue, but yet efiecting a more rapidly actingtreatment or remedy than its individual ingredients, indicates a reaction between the elements of the compound. It is believed that th61 '1S a chemical reaction between the; iodine and salicylic acid, as well as between the iodine and the mercurochrome, which is a-mercury organic compound (i. e. disodium salt of dibromhydroxymercurifluorescein) or among all three elements. Howevenirrespective of any explanation of the exact action or interaction between the elements of the compound,

it has been found to be'a fact; by clinical experiments, that the compound possesses the characteristics and properties above set forth, which-is morefthan those attributable to the simple sum of the individual properties.

Having-thus described the invention and the manner in which the same is to be performed, what-is claimed as new-andupon whichlLetters Patent is desired, is: a 1

2 I i eeepea 1. A new glroduet having therapeutic prolitions of one-pound salicylic acid, five fluid e'rties inclu 'ng a mercury derivative or diounces tincture iodine and five fluid ounces brom-fluorescem and iodine. two per cent solution of mercuroc fome in a- 2. A new roduct having therapeutic propsolvent vehicle.

erties inclu ing a salicylic, acid, iodine and a In testimony whereof have hereunto set mercury derivative of 'di-brom-fiuorescein. my hand.

3. A new roduct having therapeutic properties inclu ing substantially in the propor- CHARLES F. AMACKEII 

